International Federation of Societies of Toxicologic Pathologists
116 White Owl Trail
Mullica Hill, NJ 08062
IFSTP in conjunction with our member societies will be hosting a series of educaitonal webinars throughout the year. All IFSTP member societies are invited to participate in these webinars. Webinars are free, however, you must complete a registration form in advance of the meeting to be able to participate. Space is limited to 100 attendees and will be taken on first-come, first-serve basis.
PAST WEBINARS
The Toxicologic Pathology of
Common Kinase Targets
HOSTED BY STP-I
CO-SPONSORED BY IFSTP & IATP
Held on August 4, 2016
Speaker: Timothy LaBranche DVM, PhD, DACVP
Blueprint Medicines, Cambridge, MA
This webinar covered common toxicities associated with inhibition of cellular kinases by small molecule pharmaceuticals. The human kinome is rich with targets for anticancer and immunomodulatory therapies and this presents an opportunity for toxicologists and pathologists to help the broader medical community by characterizing the roles that kinases play in tissue function. The goal of the presentation was to shed light on some of the tissue responses associated with common kinase targets, and to highlight future opportunities in understanding the role kinases play in health and disease.
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Update on Reproductive Toxicologic Pathology
CO-SPONSORED BY IFSTP & IATP
Held on January 21, 2016
Speakers: Karen Regan and Justin Vidal
This webinar provided toxicologic pathologist throughout the Asia-Pacific region with a current issues update on the design of general toxicology studies specific to the interpretation of reproductive pathology findings from two highly-regarded experts. Justin Vidal discussed the evaluation of the male reproductive system in nonhuman primates focusing on the determination of sexual maturity and common spontaneous findings. Karen Regan described how to recognize early senescent changes in female rodents. .
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Pathology of the Posterior Segment in Ocular Toxicity Studies
HOSTED BY STP-I
CO-SPONSORED BY IFSTP & IATP
Held on December 8, 2015
Speaker: Steve Sorden
Safety studies of drug candidates designed to treat diseases of the retina are increasingly complex. Unlike many other organs, multiple antemortem tools are available to evaluate and monitor the effects of drug candidates on ocular morphology. Microscopic evaluation of the eye in toxicity studies must take into account multiple factors, including findings from various antemortem tests. The speaker will focus on important points for pathologists to consider when evaluating the posterior segment of the eye in drug safety studies, including route of administration, ocular fixation, immunohistochemistry, and correlation of microscopic findings with findings from antemortem tests.
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Regulatory Views on Pathology Results
HOSTED BY NLSTP
CO-SPONSORED BY IFSTP & IATP
Held on November 5, 2015
Speaker: Jan Willem van der Laan
Role of toxicological pathology in safety assessment of human pharmaceuticals.Safety assessment of human pharmaceuticals is a multidisciplinary challenge. Pharmacologists are involved in the discovery to find a drug for the intended target, and to check for off-target effects. General toxicologists, pharmacokineticists and pathologists are working together to describe the consequences of these effects in animal models. Translational steps are important for the prediction of the safety of the compound in humans. Important safety aspects are carcinogenicity, reproductive toxicity and immunotoxicity. All these areas have an important histopathological component, and high quality reports are essential in the evaluation of these aspects. The webinar will focus on Carcinogenicity testing of human pharmaceuticals, and highlight discussions that are ongoing, especially in relation to the International Conference on Harmonization.
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Held on July 1, 2015
Speakers: Ricardo Ochoa,DVM, PhD, DACVP, FIATP and Jeff Wolf, DVM, DACVP
Este seminario es la traducción de un seminario presentado por el Dr. Jeffrey Wolf en 2012 y esta dirigido a los toxicólogos y patologos de habla hispana y cubre lo que sabemos, lo que no sabemos y para donde va el campo de la disrupcion hormonal debida a xenobioticos. Es un seminario enfocado en la ciencia de decidir que es importante en este campo.
This webinar was presented in Spanish only!
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Held on May 11, 2015
Speaker: Alok Sharma, BVSc, MVSc, MS, PhD, DACVP, DABT
Various pharmaceuticals drugs and environmental toxins have potential to cause neurotoxicity, which is manifested as an adverse effect on the structure and/or function of the nervous system. To screen for potential neurotoxicity in rats, a combination of techniques are used including functional observational battery (FOB), study of motor activity and histopathology. This webinar provided an overview of techniques used to detect histopathologicchanges in the central and peripheral nervous system. The speaker focused on important points to consider while designing and conducting neuropathological evaluation in rats including perfusion-fixation, collection of tissues (brain, spinal cord, dorsal root ganglia, peripheral nerves, and muscles), common embedding techniques and use of histochemical stains and immunohistochemical labels to detect histopathologicchanges.
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Digital Image Analysis &Multiplexing of Biomarkers –
Part 1
HOSTED BY ESTP
CO-SPONSORED BY IFSTP & IATP
Held on April 28, 2015
Speaker: Famke Aeffner, DVM, PhD, DACVP
This webinar revisited the basic approaches of digital image analysis and it’s utility to quantify biomarker expression in both IHC and CISH-stained sections. Specific aspects covered included:
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Copyright 2014 International Federation of Societies of Toxicologic Pathologists. All rights reserved.
International Federation of Societies of Toxicologic Pathologists
116 White Owl Trail
Mullica Hill, NJ 08062