IFSTP in conjunction with our member societies will be hosting a series of educaitonal webinars throughout the year.  All IFSTP member societies are invited to participate in these webinars.  Webinars are free, however, you must complete a registration form in advance of the meeting to be able to participate.  Space is limited to 100 attendees and will be taken on first-come, first-serve basis.  

PAST WEBINARS

The Toxicologic Pathology of

Common Kinase Targets

HOSTED BY STP-I

CO-SPONSORED BY IFSTP & IATP

Held on August 4, 2016

Speaker: Timothy LaBranche DVM, PhD, DACVP

Blueprint Medicines, Cambridge, MA 

This webinar covered common toxicities associated with inhibition of cellular kinases by small molecule pharmaceuticals.  The human kinome is rich with targets for anticancer and immunomodulatory therapies and this presents an opportunity for toxicologists and pathologists to help the broader medical community by characterizing the roles that kinases play in tissue function. The goal of the presentation was to shed light on some of the tissue responses associated with common kinase targets, and to highlight future opportunities in understanding the role kinases play in health and disease.

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Update on Reproductive Toxicologic Pathology  

CO-SPONSORED BY IFSTP & IATP

 Held on January 21, 2016

Speakers: Karen Regan and Justin Vidal

This webinar provided toxicologic pathologist throughout the Asia-Pacific region with a current issues update on the design of general toxicology studies specific to the interpretation of reproductive pathology findings from two highly-regarded experts.  Justin Vidal discussed the evaluation of the male reproductive system in nonhuman primates focusing on the determination of sexual maturity and common spontaneous findings.  Karen Regan described how to recognize early senescent changes in female rodents. .   

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Pathology of the Posterior Segment in Ocular Toxicity Studies 

HOSTED BY STP-I

CO-SPONSORED BY IFSTP & IATP

Held on December 8, 2015

Speaker: Steve Sorden

Safety studies of drug candidates designed to treat diseases of the retina are increasingly complex.  Unlike many other organs, multiple antemortem tools are available to evaluate and monitor the effects of drug candidates on ocular morphology.  Microscopic evaluation of the eye in toxicity studies must take into account multiple factors, including findings from various antemortem tests.  The speaker will focus on important points for pathologists to consider when evaluating the posterior segment of the eye in drug safety studies, including route of administration, ocular fixation, immunohistochemistry, and correlation of microscopic findings with findings from antemortem tests. 

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Regulatory Views on Pathology Results

HOSTED BY NLSTP

CO-SPONSORED BY IFSTP & IATP

Held on November 5, 2015

Speaker: Jan Willem van der Laan

Role of toxicological pathology in safety assessment of human pharmaceuticals.Safety assessment of human pharmaceuticals is a multidisciplinary challenge. Pharmacologists are involved in the discovery to find a drug for the intended target, and to check for off-target effects. General toxicologists, pharmacokineticists and pathologists are working together to describe the consequences of these effects in animal models. Translational steps are important for the prediction of the safety of the compound in humans. Important safety aspects are carcinogenicity, reproductive toxicity and immunotoxicity. All these areas have an important histopathological component, and high quality reports are essential in the evaluation of these aspects. The webinar will focus on Carcinogenicity testing of human pharmaceuticals, and highlight discussions that are ongoing, especially in relation to the International Conference on Harmonization. 

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Investigaciones en disrupcion hormonal. Su cara cambiante

Hosted by LASTEP

Co-sponsored by IFSTP & IATP

 Held on July 1, 2015 

Speakers:   Ricardo Ochoa,DVM, PhD, DACVP, FIATP and Jeff Wolf, DVM, DACVP

Este seminario es la traducción de un seminario presentado por el Dr. Jeffrey Wolf en 2012 y esta dirigido a los toxicólogos y patologos de habla hispana y cubre lo que sabemos, lo que no sabemos y para donde va el campo de la disrupcion hormonal debida a xenobioticos. Es un seminario enfocado en la ciencia de decidir que es importante en este campo. 

This webinar was presented in Spanish only!

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Pathology Techniques in Rat Neurotoxicity Studies 

Hosted by STP-I

Co-Sponsored by IFSTP and IATP

 Held on May 11, 2015

Speaker:  Alok Sharma, BVSc, MVSc, MS, PhD, DACVP, DABT

Various pharmaceuticals drugs and environmental toxins have potential to cause neurotoxicity, which is manifested as an adverse effect on the structure and/or function of the nervous system. To screen for potential neurotoxicity in rats, a combination of techniques are used including functional observational battery (FOB), study of motor activity and histopathology. This webinar provided an overview of techniques used to detect histopathologicchanges in the central and peripheral nervous system. The speaker focused on important points to consider while designing and conducting neuropathological evaluation in rats including perfusion-fixation, collection of tissues (brain, spinal cord, dorsal root ganglia, peripheral nerves, and muscles), common embedding techniques and use of histochemical stains and immunohistochemical labels to detect histopathologicchanges. 

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Digital Image Analysis &Multiplexing of Biomarkers –

Part 1

HOSTED BY ESTP

CO-SPONSORED BY IFSTP & IATP

Held on April 28, 2015

Speaker: Famke Aeffner, DVM, PhD, DACVP

This webinar revisited the basic approaches of digital image analysis and it’s utility to quantify biomarker expression in both IHC and CISH-stained sections. Specific aspects covered included:

• Measurable endpoints e.g. Area-based, cell-based and object-based;
• Quality control including pre-analysis parameter control;
• The pathologist’s role in an image analysis team

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